Background: Understanding the impact of geographical aspects and population density on the incidence rate (IR) of respiratory infections in Russia is necessary for successful control under the epidemic. Aim: to estimate the increase in IR of respiratory infections in 2020 compared to the same period of 2016-2019 Materials and methods: a retrospective study of IR of COVID-19, ARI, influenza and community acquired pneumonia (CAP) in summarily (respiratory infections and COVID-19 morbidity) in the first half of 2020 in comparison with morbidity of ARI, influenza and CAP (respiratory infections morbidity) the same period of 2016-2019 in 85 regions was performed. Additionally the influence of climate on COVID-19 morbidity were estimated. Results: The highest excess of respiratory infections and COVID-19 morbidity in 2020 versus the average respiratory infections morbidity in 2016-2019 was observed in Buryatia-107.61%; Zabaykalsky Krai -134.09%; Tuva – 166.34%; the Kaliningrad region – 1023.41%; the Republic of Altai – 1212.78%; Dagestan – 2030.27%. Buryatia, Tuva, Altai and Zabaykalsky Krai are located next to the China, and also border each other. The Kaliningrad region borders on the EU countries. Dagestan has a maritime border with 3 states, including Iran, where the epidemic COVID-19 began earlier. In 43 of the 85 regions of Russia, this excess was 10-50%; in 35 subjects varied from 50% to 100%. The correlation between the incidence of COVID-19 and the population density in the regions was weak (r=0.26). The air pollution, has also a weak relationship (r=0.26) to the incidence rate. Moderate relationship was observed between the severity of negative temperatures in winter and the level of morbidity(r=-0.51). Milder climate probably contributed to the longer persistence of the virus in the environment and social activity. Conclusion: Russian regions bordering the PRC, the EU, Central Asia and the Middle East demonstrated the highest IR of influenza, ARI, CAP and COVID-19in summarility in the first part of this year versus the morbidity of influenza, ARI, CAP in average in first half of 2016-2019. IR of COVID-19 has weak correlation with population density and air pollution and moderate negative correlation with winter temperature.