ПРЕПРИНТ
О результатах, изложенных в препринтах, не следует сообщать в СМИ как о проверенной информации.
Пандемия новой коронавирусной инфекции является серьезным испытанием для мировой системы здравоохранения, а контроль за развитием эпидемического процесса является одной из главных задач в борьбе с COVID-19. Данный обзор литературы освещает проблему асимптоматического течения новой коронавирусной инфекции. Представлены его варианты, распространенность в мире и активность вовлечения в эпидемический процесс SARS-CoV-2. Показано менее стойкое формирование иммунного ответа у лиц с бессимптомной формой заболевания по сравнению клиническими формами инфекции COVID-19.
Базыкина Е. А., Троценко О. Е. 2020. ЭПИДЕМИОЛОГИЧЕСКОЕ ЗНАЧЕНИЕ БЕССИМПТОМНЫХ НОСИТЕЛЕЙ COVID-19 (ОБЗОР ЛИТЕРАТУРЫ). COVID19-PREPRINTS.MICROBE.RU. https://doi.org/10.21055/preprints-3111765
1. Al-Tawfiq JA. Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19). Travel Med Infect Dis. 2020;35:101608. doi:10.1016/j.tmaid.2020.101608
2. Lai CC, Liu YH, Wang CY, et al. Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. J Microbiol Immunol Infect. 2020;53(3):404-412. doi:10.1016/j.jmii.2020.02.012
3. Gao Z, Xu Y, Sun C, et al. A Systematic Review of Asymptomatic Infections with COVID-19. J Microbiol Immunol Infect. 2020;10.1016/j.jmii.2020.05.001. doi:10.1016/j.jmii.2020.05.001
4. [Contribution of asymptomatic and pre-symptomatic cases of COVID-19 in spreading virus and targeted control strategies]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(6):801-805. Chinese. doi: 10.3760/cma.j.cn112338-20200406-00517. PMID: 32274917
5. Wu Z, McGoogan JM. Asymptomatic and Pre-Symptomatic COVID-19 in China. Infect Dis Poverty. 2020;9(1):72. doi:10.1186/s40249-020-00679-2;
6. Huff HV, Singh A. Asymptomatic transmission during the COVID-19 pandemic and implications for public health strategies. Clin Infect Dis. 2020;ciaa654. doi:10.1093/cid/ciaa654
7. Lin C, Ding Y, Xie B, et al. Asymptomatic novel coronavirus pneumonia patient outside Wuhan: The value of CT images in the course of the disease. Clin Imaging. 2020;63:7-9. doi:10.1016/j.clinimag.2020.02.008
8. Castanheira J, Mascarenhas Gaivão A, Mairos Teixeira S, Pereira PJ, Costa DC. Asymptomatic COVID-19 positive patient suspected on FDG-PET/CT. Nucl Med Commun. 2020;41(6):598-599. doi:10.1097/MNM.0000000000001221
9. Albano D, Bertagna F, Bertoli M, et al. Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region. J Nucl Med. 2020;61(5):632-636. doi:10.2967/jnumed.120.246256
10. Meng H, Xiong R, He R, et al. CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China. J Infect. 2020;81(1):e33-e39. doi:10.1016/j.jinf.2020.04.004
11. Yu X, Yang R. COVID-19 transmission through asymptomatic carriers is a challenge to containment. Influenza Other Respir Viruses. 2020;14(4):474-475. doi:10.1111/irv.12743
12. Oran DP, Topol EJ. Prevalence of Asymptomatic SARS-CoV-2 Infection: A Narrative. Ann Intern Med. 2020;M20-3012. doi:10.7326/M20-3012
13. Hosoki K, Chakraborty A, Sur S. Molecular mechanisms and epidemiology of COVID-19 from an allergist's perspective. J Allergy Clin Immunol. 2020;S0091-6749(20)30799-5. doi:10.1016/j.jaci.2020.05.033
14. Wei L, Lin J, Duan X, et al. Asymptomatic COVID-19 Patients Can Contaminate Their Surroundings: an Environment Sampling Study. mSphere. 2020;5(3):e00442-20. doi:10.1128/mSphere.00442-20
15. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020;323(14):1406-1407. doi:10.1001/jama.2020.2565;
16. Huang L, Zhang X, Zhang X, et al. Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: A prospective contact-tracing study. J Infect. 2020;80(6):e1-e13. doi:10.1016/j.jinf.2020.03.006
17. Ye F, Xu S, Rong Z, et al. Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster. Int J Infect Dis. 2020;94:133-138. doi:10.1016/j.ijid.2020.03.042
18. Pan X, Chen D, Xia Y, et al. Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect Dis. 2020;20(4):410-411. doi:10.1016/S1473-3099(20)30114-6
19. Gao M, Yang L, Chen X, et al. A study on infectivity of asymptomatic SARS-CoV-2 carriers. Respir Med. 2020;169:106026. doi:10.1016/j.rmed.2020.106026
20. He D, Zhao S, Lin Q, et al. The relative transmissibility of asymptomatic COVID-19 infections among close contacts. Int J Infect Dis. 2020;94:145-147. doi:10.1016/j.ijid.2020.04.034
21. Chen Y., Wang A., Yi B., Ding K., Wang H., Wang J. The epidemiological characteristics of infection in close contacts of COVID-19 in Ningbo city. Chin J Epidemiol. 2020:41.
22. Miyamae Y, Hayashi T, Yonezawa H, et al. Duration of viral shedding in asymptomatic or mild cases of novel coronavirus disease 2019 (COVID-19) from a cruise ship: A single-hospital experience in Tokyo, Japan. Int J Infect Dis. 2020;97:293-295. doi:10.1016/j.ijid.2020.06.020
23. Li W, Su YY, Zhi SS, et al. Viral shedding dynamics in asymptomatic and mildly symptomatic patients infected with SARS-CoV-2. Clin Microbiol Infect. 2020;S1198-743X(20)30410-9. doi:10.1016/j.cmi.2020.07.008
24. Wu Z, McGoogan JM. Asymptomatic and Pre-Symptomatic COVID-19 in China. Infect Dis Poverty. 2020;9(1):72. doi:10.1186/s40249-020-00679-2
25. National Health Commission of the People’s Republic of China . Update on COVID-19 in China as of 24th hour on April 7, 2020. Beijing, China: National Health Commission; 2020
26. Kim GU, Kim MJ, Ra SH, et al. Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19. Clin Microbiol Infect. 2020;26(7):948.e1-948.e3. doi:10.1016/j.cmi.2020.04.040
27. Pollán M, Pérez-Gómez B, Pastor-Barriuso R, et al. Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet. 2020;S0140-6736(20)31483-5. doi:10.1016/S0140-6736(20)31483-5
28. Gallian P, Pastorino B, Morel P, Chiaroni J, Ninove L, de Lamballerie X. Lower prevalence of antibodies neutralizing SARS-CoV-2 in group O French blood. Antiviral Res. 2020;181:104880. doi:10.1016/j.antiviral.2020.104880
29. Rivett L, Sridhar S, Sparkes D, et al. Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission. Elife. 2020;9:e58728. doi:10.7554/eLife.58728
30. Korth J, Wilde B, Dolff S, et al. SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patients. J Clin Virol. 2020;128:104437. doi:10.1016/j.jcv.2020.104437
31. Schmidt SB, Grüter L, Boltzmann M, Rollnik JD. Prevalence of serum IgG antibodies against SARS-CoV-2 among clinic staff. PLoS One. 2020;15(6):e0235417. doi:10.1371/journal.pone.0235417
32. Garcia-Basteiro AL, Moncunill G, Tortajada M, et al. Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital. Nat Commun. 2020;11(1):3500. doi:10.1038/s41467-020-17318-x
33. Corradini P, Gobbi G, de Braud F, et al. Rapid Antibody Testing for SARS-CoV-2 in Asymptomatic and Paucisymptomatic Healthcare Professionals in Hematology and Oncology Units Identifies Undiagnosed Infections. Hemasphere. 2020;4(3):e408. doi:10.1097/HS9.0000000000000408
34. Patel MC, Chaisson LH, Borgetti S, et al. Asymptomatic SARS-CoV-2 infection and COVID-19 mortality during an outbreak investigation in a skilled nursing facility. Clin Infect Dis. 2020;ciaa763. doi:10.1093/cid/ciaa763
35. Gandhi M, Yokoe DS, Havlir DV. Asymptomatic Transmission, the Achilles' Heel of Current Strategies to Control Covid-19. N Engl J Med. 2020;382(22):2158-2160. doi:10.1056/NEJMe2009758
36. Nahshon C, Bitterman A, Haddad R, Hazzan D, Lavie O. Hazardous Postoperative Outcomes of Unexpected COVID-19 Infected Patients: A Call for Global Consideration of Sampling all Asymptomatic Patients Before Surgical Treatment. World J Surg. 2020;44(8):2477-2481. doi:10.1007/s00268-020-05575-2
37. Siracusano G, Pastori C, Lopalco L. Humoral Immune Responses in COVID-19 Patients: A Window on the State of the Art. Front Immunol. 2020;11:1049. doi:10.3389/fimmu.2020.01049
38. Long QX, Tang XJ, Shi QL, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med. 2020;10.1038/s41591-020-0965-6. doi:10.1038/s41591-020-0965-6
39. Choe PG, Kang CK, Suh HJ, et al. Antibody Responses to SARS-CoV-2 at 8 Weeks Postinfection in Asymptomatic Patients. Emerg Infect Dis. 2020;26(10):10.3201/eid2610.202211. doi:10.3201/eid2610.202211
40. Siracusano G, Pastori C, Lopalco L. Humoral Immune Responses in COVID-19 Patients: A Window on the State of the Art. Front Immunol. 2020;11:1049. doi:10.3389/fimmu.2020.01049
41. Altmann DM, Boyton RJ. SARS-CoV-2 T cell immunity: Specificity, function, durability, and role in protection. Sci Immunol. 2020;5(49):eabd6160. doi:10.1126/sciimmunol.abd6160
